On the Performance of PDCCH in LTE and 5G New Radio

5G New Radio (NR) Release 15 has been specified in June 2018. It introduces numerous changes and potential improvements for physical layer data transmissions, although only point-to-point (PTP) communications are considered. In order to use physical data channels such as the Physical Downlink Shared Channel (PDSCH), it is essential to guarantee a successful transmission of control information via the Physical Downlink Control Channel (PDCCH). Taking into account these two aspects, in this paper, we first analyze the PDCCH processing chain in NR PTP as well as in the state-of-the-art Long Term Evolution (LTE) point-to-multipoint (PTM) solution, i.e., evolved Multimedia Broadcast Multicast Service (eMBMS). Then, via link level simulations, we compare the performance of the two technologies, observing the Bit/Block Error Rate (BER/BLER) for various scenarios. The objective is to identify the performance gap brought by physical layer changes in NR PDCCH as well as provide insightful guidelines on the control channel configuration towards NR PTM scenarios.Comment: Globecomm 2018 workshop, 6 pages, 7 fig

Physical Layer Performance Evaluation of LTE-Advanced Pro Broadcast and ATSC 3.0 Systems

This work provides a detailed performance analysis of the physical layer of two state-of-the-art point-to-multipoint (PTM) technologies: evolved Multimedia Broadcast Multicast Services (eMBMS) and Advanced Television Systems Committee - Third Generation (ATSC 3.0). The performance of these technologies is evaluated and compared using link-level simulations, considering relevant identified scenarios. A selection of Key Performance Indicators (KPI) for the International Mobile Telecommunications 2020 (IMT-2020) evaluation process has been considered. Representative use cases are also aligned to the test environments as defined in the IMT-2020 evaluation guidelines. It is observed that ATSC 3.0 outperforms both eMBMS solutions, i.e. MBMS over Single Frequency Networks (MBSFN) and Single-Cell PTM (SC-PTM) in terms of spectral efficiency, peak data rate and mobility, among others. This performance evaluation serves as a benchmark for comparison with a potential 5G PTM solution

Pioneering Studies on LTE eMBMS: Towards 5G Point-to-Multipoint Transmissions

The first 5G (5th generation wireless systems) New Radio Release-15 was recently completed. However, the specification only considers the use of unicast technologies and the extension to point-to-multipoint (PTM) scenarios is not yet considered. To this end, we first present in this work a technical overview of the state-of-the-art LTE (Long Term Evolution) PTM technology, i.e., eMBMS (evolved Multimedia Broadcast Multicast Services), and investigate the physical layer performance via link-level simulations. Then based on the simulation analysis, we discuss potential improvements for the two current eMBMS solutions, i.e., MBSFN (MBMS over Single Frequency Networks) and SC-PTM (Single-Cell PTM). This work explicitly focus on equipping the current eMBMS solutions with 5G candidate techniques, e.g., multiple antennas and millimeter wave, and its potentials to meet the requirements of next generation PTM transmissions.Comment: SAM 2018, 5 pages, 4 fig

5G New Radio for Terrestrial Broadcast: A Forward-Looking Approach for NR-MBMS

"© 2019 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works."[EN] 3GPP LTE eMBMS release (Rel-) 14, also referred to as further evolved multimedia broadcast multicast service (FeMBMS) or enhanced TV (EnTV), is the first mobile broadband technology standard to incorporate a transmission mode designed to deliver terrestrial broadcast services from conventional high power high tower (HPHT) broadcast infrastructure. With respect to the physical layer, the main improvements in FeMBMS are the support of larger inter-site distance for single frequency networks (SFNs) and the ability to allocate 100% of a carrier's resources to the broadcast payload, with self-contained signaling in the downlink. From the system architecture perspective, a receive-only mode enables free-to-air (FTA) reception with no need for an uplink or SIM card, thus receiving content without user equipment registration with a network. These functionalities are only available in the LTE advanced pro specifications as 5G new radio (NR), standardized in 3GPP from Rel-15, has so far focused entirely on unicast. This paper outlines a physical layer design for NR-MBMS, a system derived, with minor modifications, from the 5G-NR specifications, and suitable for the transmission of linear TV and radio services in either single-cell or SFN operation. This paper evaluates the NR-MBMS proposition and compares it to LTE-based FeMBMS in terms of flexibility, performance, capacity, and coverage.This work was supported in part by the European Commission through the 5G-PPP Project 5G-Xcast (H2020-ICT-2016-2 call) under Grant 761498.Gimenez, JJ.; Carcel, JL.; Fuentes, M.; Garro, E.; Elliott, S.; Vargas, D.; Menzel, C.... (2019). 5G New Radio for Terrestrial Broadcast: A Forward-Looking Approach for NR-MBMS. IEEE Transactions on Broadcasting. 65(2):356-368. https://doi.org/10.1109/TBC.2019.291211735636865

A hierarchical AI-based control plane solution for multitechnology deterministic networks

Following the Industry 4.0 vision of a full digitiSation of the industry, time-critical services and applications, allowing network infrastructures to deliver information with determinism and reliability, are becoming more and more relevant for a set of vertical sectors. As a consequence, deterministic network solutions are progressively emerging, albeit they are still bounded to specific technological domains. Even considering the existence of interconnected deterministic networks, the provision of an end-to-end (E2E) deterministic service over them must rely on a specific control plane architecture, capable of seamlessly integrate and control the underlying multi-technology data plane. In this work, we envision such a control plane solution, extending previous works and exploiting several innovations and novel architectural concepts. The proposed control architecture is service-centric, in order to provide the necessary flexibility, scalability, and modularity to deal with a heterogenous data plane. The architecture is hierarchical and encompasses a set of management platforms to interact with specific network technologies overarched by an E2E platform for the management, monitoring, and control of E2E deterministic services. Furthermore, Artificial Intelligence (AI) and Digital Twinning are used to enable network predictability and automation, as well as smart resource allocation, to ensure service reliability in dynamic scenarios where existing services may terminate and new ones may need to be deployed

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Genome-wide association studies have generated an increasing number of common genetic variants associated with neurological and psychiatric disease risk. An improved understanding of the genetic control of gene expression in human brain is vital considering this is the likely modus operandum for many causal variants. However, human brain sampling complexities limit the explanatory power of brain-related expression quantitative trait loci (eQTL) and allele-specific expression (ASE) signals. We address this, using paired genomic and transcriptomic data from putamen and substantia nigra from 117 human brains, interrogating regulation at different RNA processing stages and uncovering novel transcripts. We identify disease-relevant regulatory loci, find that splicing eQTLs are enriched for regulatory information of neuron-specific genes, that ASEs provide cell-specific regulatory information with evidence for cellular specificity, and that incomplete annotation of the brain transcriptome limits interpretation of risk loci for neuropsychiatric disease. This resource of regulatory data is accessible through our web server, http://braineacv2.inf.um.es/

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability

Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Pioneering studies on LTE eMBMS: Towards 5G Point-to-Multipoint Transmissions

The first 5G (5th generation wireless systems) New Radio Release-15 was recently completed. However, the specification only considers the use of unicast technologies and the extension to point-to-multipoint (PTM) scenarios is not yet considered. To this end, we first present in this work a technical overview of the state-of-the-art LTE (Long Term Evolution) PTM technology, i.e., eMBMS (evolved Multimedia Broadcast Multicast Services), and investigate the physical layer performance via link-level simulations. Then based on the simulation analysis, we discuss potential improvements for the two current eMBMS solutions, i.e., MBSFN (MBMS over Single Frequency Networks) and SCPTM (Single-Cell PTM). This work explicitly focus on equipping the current eMBMS solutions with 5G candidate techniques, e.g., multiple antennas and millimeter wave, and its potentials to meet the requirements of next generation PTM transmissions

A hierarchical AI-based control plane solution for multi-technology deterministic networks

Following the Industry 4.0 vision of a full digitization of the industry, time-critical services and applications, allowing network infrastructures to deliver information with determinism and reliability, are becoming more and more relevant for a set of vertical sectors. As a consequence, deterministic network solutions are progressively emerging, albeit they are still bounded to specific technological domains. Even considering the existence of interconnected deterministic networks, the provision of an end-to- end (E2E) deterministic service over them must rely on a specific control plane architecture, capable of seamlessly integrate and control the underlying multi-technology data plane. In this work, we envision such a control plane solution, extending previous works and exploiting several innovations and novel architectural concepts. The proposed control architecture is service-centric, in order to provide the necessary flexibility, scalability, and modularity to deal with a heterogenous data plane. The architecture is hierarchical and encompasses a set of management platforms to interact with specific network technologies overarched by an E2E platform for the management, monitoring, and control of E2E deterministic services. Furthermore, Artificial Intelligence (AI) and Digital Twinning are used to enable network predictability and automation, as well as smart resource allocation, to ensure service reliability in dynamic scenarios where existing services may terminate and new ones may need to be deployed